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A Video Game Developed To Detect Alzheimer’s Disease Seems To Be Working

Helios

Member
Source:
https://kotaku.com/a-video-game-developed-to-detect-alzheimer-s-disease-se-1834331632

Sea Hero Quest is a video game developed in partnership with Germany’s Deutsche Telekom, game studio Glitchers and several European universities and it is designed to identify individuals who might have early and mild symptoms of dementia that medical tests aren’t able to detect.

Sea Hero Quest was built as a way to identify people who might be at risk of Alzheimer’s but who aren’t yet suffering any major symptoms of the disease and according to a study recently published in the journal PNAS, it seems the game is effective.
In Sea Hero Quest, which is a VR game, players have to navigate and control a virtual boat. They are given a map and shown checkpoints, then the map is taken away and players must navigate to these checkpoints in the game world without the map.

According to researchers, every two minutes spent playing the game is equal to five hours of lab-based research. Because Sea Hero Quest has been out for a few years and downloaded and played by over three million players they’ve collected the equivalent of 1,700 years of research data on Alzheimer’s.
Researchers involved with the project studied people who carried the APOE4 gene, which is thought to increase that person’s risk of developing dementia, as they played the game. They then compared these people’s results to the results of folks who played the game who don’t have that gene.

“We found that people with a high genetic risk, the APOE4 carriers, performed worse on spatial navigation tasks. They took less efficient routes to checkpoint goals,” said Professor Michael Hornberger, a member of the team.
 

Humdinger

Member
I'm going to be a little skeptical. First, it's a correlation between the gene and spatial reasoning. Although it's interesting, that's not the same as a link between the game and Alzheimer's. Second, they aren't necessarily people with early Alzheimer's. They're just people with a gene that puts them at risk. There's no way to know if someone has Alzheimer's until they develop it, and these people haven't developed it. So it's an association between a gene and spatial reasoning among people who may or may not have Alzheimer's.

I would also take issue with the claim that "every two minutes spent playing the game is equal to five hours of lab-based research" for detecting Alzheimer's. Even early stage dementia (which shows up as mild cognitive impairment) is fairly easy to detect using standard neuropsychological tests. They don't take 5 hours, and they're much more comprehensive than this test -- which by the way is only picking up on spatial navigation deficits, which are not the core problem in Alzheimer's (that's memory), which is another problem with the study.

Sorry to be critical. Maybe the research will be useful down the road somewhere. I think the press often plays a role in making research findings sound more impressive than they really are.
 
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This is interesting, but how did they account for other variables which could reduce performance on the task? Dementia can impact working memory (obviously), but so can numerous other conditions.
 
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