He did say in one interview that he watched Anita's videos during his time on Uncharted 4 it was I believe and her influence inspired him to make changes to characters.
Here's the transcript of said Kotaku interview.
You’ve said in the past that you’ve been influenced by Anita Sarkeesian’s Feminist Frequency videos and the larger conversation about diversity and representation in games. How did that affect Uncharted 4?
Druckmann: When I’m introducing and describing a new character to our lead character concept artist, constantly she will ask, “What if it was a girl?” And I’m like, Oh, I didn’t think about that. Let me think, does that affect or change anything? No? Cool, that’s different. Yeah, let’s do it.
Initially, in the epilogue, it was Nate’s son. Something similar happened with the mansion they go into. That was an old English guy’s house. She asked, Well, what if it was a woman?
You have some sexist focus testers who were really upset by Nadine beating up Nate, and really upset at the end when it was Nate’s daughter. To the point where we had to ask one guy to leave. In his core, it just affected him. He was cursing, “Not you, too, Naughty Dog! Goddammit. I guess I’m done with Uncharted, if you guys ever make another one, with his daughter. This fucking bullshit.”
And I was like, Wow, why does that matter?
I get the YouTube channel was going a bit over the top but it's a bit scary how he will change his mind like that lmao.